Gut Biome Bank

Restore

Your Microbiome with Your

Own Microbiome Bacteria

What is Gut Biome Banking?

The concept powering the Gut Biome Bank is that during a time of optimal or good health the composition of the gut microbiome is collected via a stool sample. That stool sample is shipped to our lab, where it is processed and stored in capsules.  The capsules are readily available to be used in the future to restore the gut microbiome of the individual who provided the stool.

Using this technology, the bacteria composition of the gut microbiome is able to be restored to 75% of what it was at the time of collection in about 1 week or sooner providing support for the immune system and protecting from pathogens. (1)

“I started the Gut Biome Bank because this service didn’t exist and I wanted my family to benefit from this technology. I believe that the ability to quickly restore your gut microbiome to a robust and diverse composition of gut bacteria following an illness is a revolutionary step to living a long and vibrant life. I love sharing my mission with others. When you book a Free consultation, you will speak with the Founder and CEO. I can’t wait to speak with you and to help your family begin your Gut Biome Health Journey.


Kyle Cetrulo

Founder and CEO

“All disease begins in the gut” Hippocrates

The gut microbiome refers to the trillions of microbes inhabiting the human gut. The gut microbiome plays an important role in many aspects of our health. When the balance of good and bad bacteria in the gut gets disrupted, it can lead to various health issues. One way to restore this balance is through the Gut Biome Bank’s personal/autologous fecal transplant capsules.

These capsules act like a "reset" button for your gut bacteria. They reintroduce the good bacteria that were present when you were healthy helping to crowd out any bad bacteria that may have taken over contributing to an illness or disorder.

The Gut Biome Bank’s technology is the Fastest method to restore the gut microbiome to a Healthy State.

Utilizing the Gut Biome Bank personal gut microbiome capsule approach to has been shown to restore the composition of the gut microbiome up to 75% of the collected bacteria composition in about a week. Diversity of the gut microbiome is key for a healthy gut microbiome. Diet and Probiotics alone can take upwards of 6 months to return the gut microbiome to a diverse composition of bacteria strains that represent a healthy state.(1)

Speed is Your Friend

The speed of the restoration is vitally important because as long as the gut microbiome is in a state of dysbiosis there exists an opportunity for pathogens and parasites to take hold because the nutrients that they feed on to exist are readily available. When over 50 strains of good bacteria are working as a community, the good bacteria consume the nutrients that the pathogens require and without nutrients to feed on they are not able to survive. (21)

How Gut Biome Bank Works with BioHackers

Gut Biome Bank enables Biohacking clients interested in longevity to establish a baseline gut microbiome composition. Clients are encouraged to bank multiple collections annually through our subscription model. The first collection establishes a Baseline, which can be restored by ingesting the capsules if needed. As Biohackers improve their gut microbiome through various modalities, they continually add to their inventory of capsules. The goal is to generate a lifetime supply of healthy capsules, ensuring their gut microbiome never drops below the Baseline and only improves. The Gut Biome Bank allows for unlimited collections, enabling clients to maintain a healthy gut microbiome throughout their lives. For example, it is theoretically possible for a 90-year-old to have the gut microbiome of a 25-year-old if they established their Baseline at that age.

POST ANTIBIOTIC USE

Antibiotic use completely disrupts the gut microbiome composition and diversity. 

Before antibiotic treatment, a fecal sample is collected from the client and is processed and stored in capsules that contain the individual's unique gut microbiome composition.

Following a course of antibiotic therapy, the client is able to reintroduce his own native microbiome bacteria via the Gut Biome capsules which recolonize the gut and restore the microbiome to its pre-antibiotic state.

By quickly restoring the native gut microbiome, Gut Biome Bank may help prevent the overgrowth of harmful bacteria which can cause severe infections.

Gut Biome Bank uses the client's own microbiome bacteria via a personalized treatment that may be more effective and have fewer risks compared to using donor fecal material.(Ref 1-8) 

DIETARY INTERVENTION

The Gut Biome Bank personal gut microbiome capsules could potentially help prevent weight cycling by maintaining some of the health benefits achieved during weight loss.   Restoring a person's own gut bacteria back into their body after successful weight loss with the Gut Biome Bank’s capsules could help maintain reduced levels of hormones and markers like leptin, CRP, IL-6, and cholesterol.

Restoring the gut bacteria also preserves the overall bacterial community composition to be more similar to the post-weight loss state.

Gut Biome Bank offers a potential strategy to sustain the metabolic improvements attained through weight loss, thereby reducing the negative effects of weight cycling. By maintaining a favorable gut microbiome composition, Gut Biome Bank may help individuals preserve some of the health benefits they achieved through a strict diet and exercise program.(Ref 9-11)

 

SUPPORT FOR CANCER

Cancer patients who undergo chemotherapy, radiation, and stem cell transplantation face a high risk of infection, which is a leading cause of death. Antibiotics are routinely used in stem cell transplantation.  

Collecting and preserving a patient's gut microbiome prior to cancer treatment with Gut Biome Bank could help mitigate the negative effects of antibiotics and quickly restore the microbiome in order to support the immune system and lessen the risk of complications.

With over 1 million patients undergoing chemotherapy or radiation annually in the United States, the potential impact of implementing microbiome restoration could be significant.

Implementing microbiome restoration for cancer patients has been shown to lower the risk of GvHD and the relapse within 5 years and could ultimately lead to better quality of life for the patient.(Ref 12-20)

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Important References

Personal/Auto Fecal Transplant:

  1. Suez J, Zmora N, Zilberman-Schapira G, et al. Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT. Cell. 2018;174(6):1406-1423.e16. doi: 10.1016/j.cell.2018.08.047

  2. Zmora N, Zilberman-Schapira G, Suez J, et al. Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell. 2018;174(6):1388-1405.e21. doi:10.1016/j.cell.2018.08.041

  3. Basson AR, Zhou Y, Seo BJ, Rodriguez-Palacios A, Cominelli F. Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease. Transl Res. 2020;226:1-11. doi:10.1016/j.trsl.2020.05.008

  4. Bulow C, Langdon A, Hink T, et al. Impact of Amoxicillin-Clavulanate followed by Autologous Fecal Microbiota Transplantation on Fecal Microbiome Structure and Metabolic Potential. mSphere. 2018;3(6):e00588-18. doi:10.1128/mSphereDirect.00588-18

  5. Petrof EO, Gloor GB, Vanner SJ, et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut. Microbiome. 2013;1(1):3. doi:10.1186/2049-2618-1-3

  6. Ng SC, Kamm MA, Yeoh YK, et al. Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE). Gut. 2020;69(1):83-91. doi:10.1136/gutjnl-2019-319407

  7. Zilberman-Schapira G, Zmora N, Itav S, Bashiardes S, Elinav H, Elinav E. The gut microbiome in human immunodeficiency virus infection. BMC Med. 2016;14(1):83. doi:10.1186/s12916-016-0625-3

  8. Suez J, Elinav E. The path towards microbiome-based metabolite treatment. Nat Microbiol. 2017;2:17075. doi:10.1038/nmicrobiol.2017.75

    Weight Loss and Dietary Intervention:

  9. Rinott E, Youngster I, Meir AY, et al. Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions. Eur J Intern Med. 2021;92:17-23. doi:10.1016/j.ejim.2021.03.038

  10. Rinott E, Youngster I, Yaskolka Meir A, et al. Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain. Gastroenterology. 2021;160(1):158-173.e10. doi:10.1053/j.gastro.2020.08.041

  11. Leong KSW, Jayasinghe TN, Wilson BC, et al. Effects of Fecal Microbiome Transfer in Adolescents With Obesity: The Gut Bugs Randomized Controlled Trial. JAMA Netw Open. 2020;3(12):e2030415. doi:10.1001/jamanetworkopen.2020.30415

    Cancer and Autologous FMT:

  12. Clinical Trail at Memorial Sloan Kettering Hospital https://www.mskcc.org/news/fecal-transplants-proven-restore-health-promoting-bacteria-01 https://clinicaltrials.gov/study/NCT02269150?cond=NCT02269150&rank=1

  13. Taur, Y. et al. Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Sci Transl Med 10, eaap9489 (2018). https://www.science.org/doi/10.1126/scitranslmed.aap9489

  14. Pamer, E. G., Taur, Y., Jenq, R. & van den Brink, M. R. M. Impact of the intestinal microbiota on infections and survival following hematopoietic stem cell transplantation. Blood 124, SCI-48 (2014). https://doi.org/10.1182/blood.V124.21.SCI-48.SCI-48

  15. Elinav E, Garrett WS, Trinchieri G, Wargo J. The cancer microbiome. Nat Rev Cancer. 2019;19(7):371-376. doi:10.1038/s41568-019-0155-3

  16. Li A, Bowen JM, Ball IA, et al. Autologous Faecal Microbiota Transplantation to Improve Outcomes of Haematopoietic Stem Cell Transplantation: Results of a Single-Centre Feasibility Study. Biomedicines. 2023;11(12):3274. doi:10.3390/biomedicines11123274

  17. Pamer, E. G. et al. Bacterial and Bacteriophage Consortia Are Associated with Reduced Risk of Intestinal Domination by Antibiotic-Resistant Bacteria in Hematopoietic Cell Transplant Recipients. Blood 142, 477 (2023). https://doi.org/10.1182/blood-2022-171014

  18. Shono Y. Gut microbiota and graft-versus-host disease: broad-spectrum antibiotic use increases post-allogeneic hematopoietic stem cell transplant graft-versus-host disease-related mortality. Rinsho Ketsueki. 2017;58(7):835-842. doi:10.11406/rinketsu.58.835

  19. Henig I, Yehudai-Ofir D, Zuckerman T. The clinical role of the gut microbiome and fecal microbiota transplantation in allogeneic stem cell transplantation. Haematologica. 2021;106(4):933-946. doi:10.3324/haematol.2020.247395

  20. Pession A, Zama D, Muratore E, et al. Fecal Microbiota Transplantation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review. J Pers Med. 2021;11(2):100. doi:10.3390/jpm11020100

    Importance of a Diverse Gut Microbiome:

  21. Spragge, F., Bakkeren, E., Jahn, M. T., Araujo, E. B. N., Pearson, C. F., Wang, X., Pankhurst, L., Cunrath, O., & Foster, K. R. Microbiome diversity protects against pathogens by nutrient blocking. Science 382, no. 6676 (2023). https://doi.org/10.1126/science.ade6201